J Neurol Neurosurg Psychiatry 2001;71:679-681
( November )
Short report
The range of multiple sclerosis associated with neurofibromatosis
type 1
P Perini, P Gallo
First Neurological
Clinic, Multiple Scelrosis Centre, Department of Neurology and
Psychiatry, University of Padova, Via Giustiniani 5, 35128 Padova,
Italy
Correspondence to: Dr P Gallo
paologallo{at}unipd.it
Received 14 December
2000 and in revised form 20 April 2001;
Accepted 25 April
2001
Multiple sclerosis associated with neurofibromatosis type 1 (NF1) is a very rare event. Seven patients with multiple sclerosis and
NF1 are described in the literature, and all were reported to have the
primary progressive form of multiple sclerosis. Three new patients with
NF1 that developed multiple sclerosis are described and it is shown
that the range of multiple sclerosis associated with NF1 includes the
relapsing forms of the disease. The risk of having both NF1 and
multiple sclerosis in north east Italy is higher than would be expected
based on the prevalence rates of the two diseases.
Keywords:
multiple sclerosis;
neurofibromatosis
© 2001 by Journal of Neurology, Neurosurgery, and Psychiatry
