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General neurology
Review
Evolving evidence in adult idiopathic intracranial hypertension: pathophysiology and management
  1. Susan P Mollan1,
  2. Fizzah Ali2,
  3. Ghaniah Hassan-Smith2,3,
  4. Hannah Botfield2,
  5. Deborah I Friedman4,5,
  6. Alexandra J Sinclair2,3
  1. 1Birmingham Neuro-Ophthalmology Unit, Ophthalmology Department, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK
  2. 2Neurometabolism, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
  3. 3Neurology Department, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK
  4. 4Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
  5. 5Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
  1. Correspondence to Dr Alex J Sinclair, Neurometabolism, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; a.b.sinclair{at}bham.ac.uk

Abstract

Idiopathic intracranial hypertension (IIH) is a rare but important disease associated with significant morbidity. There is an expected rise in prevalence in line with the escalating global burden of obesity. Modern revisions in the terminology and diagnostic criteria for IIH help guide clinicians in investigations and researchers in standardising recruitment criteria for clinical trials. The pathophysiology of IIH is incompletely characterised; suggested underpinning mechanisms include the role of cerebrospinal fluid regulation as well as metabolic and endocrinological perspectives. Recent treatment trials are providing insights into the management but debate still surrounds key areas in treatment. This review will provide an up-to-date discussion on the potential pathogenic mechanisms and management of IIH.

  • BENIGN INTRACRAN HYP
  • CSF DYNAMICS
  • HEADACHE
  • NEUROOPHTHALMOLOGY

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

https://doi.org/10.1136/jnnp-2015-311302

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