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PAPER |
1 Physical Medicine and Rehabilitation Department, AP-HP, GH Lariboisière-F Widal, University Paris 7, France
2 Clinical Research Unit, Lariboisière-Saint Louis, University Paris 7, France
Correspondence to:
Correspondence to:
Dr Alain P Yelnik
AP-HP, GH Lariboisière-F Widal, Physical Medicine and Rehabilitation Department, 200 rue du Faubourg Saint Denis, 75010 Paris, France; alain.yelnik{at}lrb.aphp.fr
Received 7 August 2006
In final revised form 11 October 2006
Accepted for publication 12 October 2006
 | ABSTRACT |
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 TOP ABSTRACT PATIENTS AND METHODRESULTSDISCUSSIONCONCLUSIONREFERENCES |
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Methods: A single dose of botulinum toxin A (500 Speywood units) or placebo was injected into the subcapularis muscle. Pain was assessed using a 10 point verbal scale. Subscapularis spasticity was assessed by the change in passive shoulder lateral rotation and abduction. Upper limb spasticity was assessed using the Modified Ashworth Scale for shoulder medial rotators, and elbow, wrist and finger flexors. Assessments were carried out at baseline and at weeks 1, 2 and 4.
Results: Twenty patients (10 patients per group), 11 with ischaemic stroke and 9 with haemorrhagic stroke, completed the study. Pain improvement with botulinum toxin A was observed from week 1; score difference from baseline at week 4 was 4 points versus 1 point with placebo (p = 0.025). Lateral rotation was also improved, with a statistically significant difference compared with placebo at week 2 (p = 0.05) and week 4 (p = 0.018). A general improvement in upper limb spasticity was observed; it was significant for finger flexors at week 4 (p = 0.025).
Conclusions: Subscapularis injection of botulinum toxin A appears to be of value in the management of shoulder pain in spastic hemiplegic patients. The results confirm the role of spasticity in post-stroke shoulder pain.
Abbreviations: MAS, Modified Ashworth Scale
Pain and spastic shoulder are frequent in hemiplegia following a stroke. Shoulder pain is a major problem for these patients, interfering with physiotherapy, sleep and daily activities. It is usually due to local causes: algoneurodystrophy (shoulder–hand syndrome), capsulitis, gleno-humeral subluxation and also spasticity because of the prolonged muscular contracture and possible tendinopathies.1–4 These causes can be associated, especially spasticity and algoneurodystrophy in severe hemiplegia, and patients exhibit the typical arm posture: adduction and medial rotation of the shoulder, and flexion of the elbow, wrist and finger.
Different approaches are used for treatment of pain in such patients, depending on the mechanism involved. Oral medications for pain, as those for spasticity, are usually ineffective or insufficient. Treatment of algoneurodystrophy and capsulitis mainly consists of corticosteroids, systemic treatment being more effective than local administration.3,5 To treat spasticity or its consequences, transection of the subscapularis tendon6,7 or subcapularis nerve block8,9 has been reported, but these treatments are not in common use. Botulinum toxin A has been shown to be effective in reducing spasticity and increasing the passive range of motion of the spastic upper limb in hemiplegic patients10–14 with a real functional benefit.15 The effect of botulinum toxin A on shoulder pain after a stroke has not been systematically studied. However, improvement of pain by the toxin has been reported in a placebo controlled study, although pain was not the main objective of the study.15 A beneficial effect has also been observed in an open study.16 Other controlled studies in which upper limb pain was assessed failed to show a significant reduction in pain.10–12
No specific treatment of the spastic shoulder muscles has been studied. Suprasupinator and infrasupinator muscles are not involved in painful contracted shoulder,17 and among the muscles implicated in medial rotation, the subscapularis and pectoralis muscles undoubtedly play a major role,18 with apparent pre-eminence of the subscapularis muscle.19 In a recent study of three cases, injection of botulinum toxin A into the subscapularis muscle was shown to reduce pain and improve the passive range of motion.18
Based on these observations, we formed the hypothesis that shoulder pain occurring in patients with spastic hemiplegia, even with limited range of motion compatible with capsulitis, can be relieved by reducing the spasticity of the main medial rotator muscle (ie, the subscapularis muscle). Therefore, we conducted the present study to further assess the beneficial effect of injection of botulinum toxin A (Dysport) into the subscapularis muscle on shoulder pain. An improvement in the passive range of motion was expected as a parameter of the efficacy of botulinum toxin on spasticity and as a possible secondary benefit.
| PATIENTS AND METHOD |
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TOPABSTRACTPATIENTS AND METHODRESULTSDISCUSSIONCONCLUSIONREFERENCES |
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Treatment
Treatment was allocated by computerised randomisation. Patients were seated on the edge of their bed, with the arm against the trunk, the shoulder being slightly pushed backward by an assistant to produce as much winging of the scapula as possible. An 0.8 mm diameter, 100 mm needle coated with Teflon, except for the tip, was inserted in the medial scapular border, slightly below the level of the spine of the scapula, along its anterior face, pointing at the acromion, as previously described.18 Before the intramuscular injection, the needle was used as a stimulation electrode to detect the motor point where minimal stimulation induces maximum internal rotation, and then botulinum toxin A (Dysport, 500 Speywood units) or placebo (all constituents of Dysport solvent) was injected while pulling back the needle by 1–2 cm. In addition, all patients received after treatment, on weekdays—non-standardised physical therapy for stretching, spasticity inhibition and increasing active motion when possible.
Methods of assessment
Pain was assessed using a 10 point verbal scale or, for aphasic patients only (one in the placebo group, three in the toxin group), a visual analogue scale. Subscapularis muscle spasticity was assessed, with the patient sitting, by a range of motion inducing a strong resistance after slow stretching in passive lateral rotation and abduction measured in degrees. Assessment of the spasticity of the whole upper limb was carried out, with the patient sitting, using the MAS for shoulder medial rotators, elbow flexors, wrist flexors and fingers flexors. These assessments were carried out at baseline and at weeks 1, 2 and 4. In addition to the assessments of pain, consumption of analgesics at baseline and at week 4 was recorded.
The change from baseline in pain associated with spasticity, as assessed by the patient, was calculated at each visit. The change in consumption of analgesics between baseline and week 4 was coded by the investigator as increased (increasing the dosage or changing to another analgesic), no change or decreased. The change in shoulder range of motion was assessed by the change from baseline in lateral rotation and in abduction values at week 1, week 2 and week 4 visits. Changes from baseline in MAS scores for each muscle group were calculated at each visit.
Statistical analyses
As the statistical distributions of the pain and range of motion parameters were a priori not Gaussian, non-parametric tests were used. As calculated according to the method of Noether,21 the population required to detect a difference in the distribution of values between the two groups with an 80% power and a two sided 5% confidence level was 24 patients (ie, 12 per group). Characteristics of the patients in the two groups at baseline were compared using exact 95% confidence intervals (CI). Covariance analyses adjusted on values at baseline were used to compare pain reduction and change in range of motion between the two groups at each visit.22 A 
2 test was used for comparisons of differences in MAS scores.
| RESULTS |
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TOPABSTRACTPATIENTS AND METHODRESULTSDISCUSSIONCONCLUSIONREFERENCES |
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. As determined from exact 95% CI, there were no statistically significant differences between groups for age or sex. The same was true for all parameters of disease history and for the time elapsed since cerebral stroke.
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. There was no statistically significant difference in baseline pain scores between the two groups. As shown by the mean changes from baseline (fig 1), pain improvement was observed throughout the observation period following Dysport, while minimal post-treatment changes were observed after placebo administration. Pain improvement appeared as early as week 1 and was significantly different from baseline (4 points vs 1 point in the placebo group; p = 0.025) at week 4. Consumption of analgesics in the Dysport group was unchanged in 5/6 patients and increased in only 1/6 patients. In the placebo group, it was unchanged in 2/5 patients and increased in 3/5 patients. However, the difference in consumption between the two groups was not statistically significant.
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. Median baseline values for the two parameters were similar at baseline and showed wide individual variations. In the Dysport group, the amplitude of external rotation was improved as early as week 1, showing a change from a median of 0° at baseline to 10°. Change from baseline in external rotation became statistically significant compared with placebo at week 2 (p = 0.05) and even more so at week 4 (p = 0.018). Improvement in abduction was less marked and was not statistically significant compared with placebo (table 3).
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As time elapsed after stroke was different between the groups (although this was not significant), a post hoc analysis was conducted to confirm that the observed effect in the Dysport group was not caused by previous subscapularis muscle treatment in that group. However, it appeared that the longer the time after stroke, the better was the effect. Thus taking into account the time elapsed since the cerebral lesion, covariance analysis22 showed stronger statistical results, with pain being significantly reduced at week 2 (p = 0.042) and at week 4 (p = 0.007), and improvement in lateral rotation being significant at week 2 (p = 0.019) and at week 4 (p = 0.002).
Tolerance
During the 4 week study period, three patients of the Dysport group experienced treatment unrelated adverse events: moderate orchitis, mild influenza and vasovagal syncope. In the placebo group, one patient experienced severe injection pain and pain thereafter, probably related to the injection process rather than to the placebo itself; another patient experienced somnolence.
| DISCUSSION |
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TOPABSTRACTPATIENTS AND METHODRESULTSDISCUSSIONCONCLUSIONREFERENCES |
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The population size may have hindered the evaluation of the efficacy of botulinum toxin A on the range of motion of the spastic shoulder. Sample size estimation was 24 patients based on an expected large effect size. However, the difficulty in recruitment limited the study population to 20. This difficulty was mainly because of the impossibility, in the time frame of this study, to concurrently treat other spastic muscle groups, which was difficult to accept, as spasticity in hemiplegic patients is not usually limited to the shoulder. Despite the reduced population, the results retained a sufficient statistical power.
The injection technique used was derived from that described for subscapular motor point block8 but patient position was modified, as previously proposed.18 In our experience, keeping the patient seated makes the injection easier, as the scapula is maintained separated from the thorax by an assistant standing in front of the patient and pushing back the shoulder. In this position, the subscapularis muscle is usually not difficult to find. The best response to electrostimulation is usually obtained between 6 and 8 cm from the edge of the scapula. Nevertheless, in the present study, one patient (on placebo) suffered severe pain on injection because of the conflict of the needle and the anterior face of the scapula.
The reduction in pain by subscapular injection of botulinum toxin A, with a concurrent improvement in shoulder range of motion observed in the present study, confirms the role of spasticity in hemiplegic shoulder pain. Currently, the treatment of hemiplegic shoulder pain focuses on algoneurodystrophy or capsulitis, often considered the main causes of pain. Yet, the contribution of spasticity deserves to be systematically considered because pain is more frequent in spastic patients than in flaccid patients.1,4 The possible efficacy of triamcinolone injection to relieve pain supposedly related to capsulitis in hemiplegic patients with a limited range of motion, as reported by some authors,23 has not been confirmed in a randomised, placebo controlled trial.5 Moreover, our results confirm that the limited range of passive lateral rotation and limited abduction, the usual criteria of capsulitis, can be due to spasticity in hemiplegic patients. Surprisingly, the effect of botulinum toxin A in relieving pain of the shoulder or the upper limb after stroke has not been systematically studied. The present study is the first to focus specifically on pain related to spasticity in post-stroke hemiplegic patients, with specific treatment of the shoulder muscles. Our results confirm those observed in three previously published cases.18
| CONCLUSION |
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TOPABSTRACTPATIENTS AND METHODRESULTSDISCUSSIONCONCLUSIONREFERENCES |
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| FOOTNOTES |
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Competing interests: In the past 5 years, AY and FC have been reimbursed by Ipsen Pharma, the manufacturer of Dysport, for attending several conferences.
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TOPABSTRACTPATIENTS AND METHODRESULTSDISCUSSIONCONCLUSIONREFERENCES |
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Relevant Article
This article has been cited by other articles:
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  K S de Boer, H J Arwert, J H de Groot, C G M Meskers, A D R. Mishre, and J H Arendzen Shoulder pain and external rotation in spastic hemiplegia do not improve by injection of botulinum toxin A into the subscapular muscle J. Neurol. Neurosurg. Psychiatry, May 1, 2008; 79(5): 581 - 583. [Abstract] [Full Text] [PDF]
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 J.-Y. Lim, J.-H. Koh, and N.-J. Paik Intramuscular Botulinum Toxin-A Reduces Hemiplegic Shoulder Pain: A Randomized, Double-Blind, Comparative Study Versus Intraarticular Triamcinolone Acetonide Stroke, January 1, 2008; 39(1): 126 - 131. [Abstract] [Full Text] [PDF]
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A. B Ward Hemiplegic shoulder pain J. Neurol. Neurosurg. Psychiatry, August 1, 2007; 78(8): 789 - 789. [Full Text] [PDF]
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