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Contributors PD was involved in the drafting and revising the manuscript, conception of the study, analysis and interpretation of data, final approval. GH was involved in revising the manuscript, acquisition of data, analysis and interpretation of data, final approval. EB was involved in revising the manuscript, acquisition of data, analysis and interpretation of data, final approval. MO was involved in revising the manuscript, conception of the study, analysis and interpretation of data, final approval. PD takes responsibility for the integrity of the data and the accuracy of the data analysis.
Competing interests EB has received honoraria for lectures, from Biogen and Bayer Vital. MO has received scientific support, travel support and/or honoraria, from Biogen Idec, Novartis, Sanofi-Aventis, Genzyme, Pfizer, Teva and Heel, as well as receiving research grants from Allergan, Electrocore, Heel and the German Ministry for Education and Research (BMBF).
Patient consent Obtained.
Ethics approval Ethics committee of Asklepios clinics.
Provenance and peer review Not commissioned; externally peer reviewed.