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Multicentre European study of thalamic stimulation in essential tremor: a six year follow up
  1. O Sydow1,
  2. S Thobois2,*,
  3. F Alesch3,
  4. J D Speelman4,
  5. study collaborators
  1. 1Department of Neurology, Karolinska Hospital, Stockholm, Sweden
  2. 2Department of Neurology D, Wertheimer Neurological and Neurosurgical Hospital, Lyon, France
  3. 3Department of Neurosurgery, University of Vienna, Austria
  4. 4Department of Neurology, Academic Medical Centre, University of Amsterdam, Netherlands
  1. Correspondence to:
 Dr Olof Sydow
 Department of Neurology, Karolinska Hospital, 17176 Stockholm, Sweden;olof.sydowks.se

Abstract

Background: Thalamic stimulation is an efficient treatment for disabling essential tremor, as previously shown, but follow up has mostly been short term.

Objectives: To see whether good results can be maintained in the longer term.

Methods: 37 patients with essential tremor had implantation of a thalamic stimulator, either unilaterally or bilaterally. The results at one year have been reported earlier. After six years, 19 patients were available for follow up. The main instrument for evaluation was the essential tremor rating scale. The patients were examined with pulse generators turned on and off.

Results: In the majority of patients, the very good results with stimulation seen at one year were maintained after a mean of 6.5 years. The reduction in tremor scores and improvement in activities of daily living were highly significant compared with baseline and with the stimulation turned off. There were few serious adverse events. Minor side effects related to stimulation were common. Few device related complications were observed and most could be resolved.

Conclusions: Good reduction in tremor can be maintained for more than six years in the majority of these severely disabled patients. Thalamic stimulation can be recommended in essential tremor where there is insufficient response to drug treatment. Surgical procedures and follow up should be concentrated in relatively few centres, which will thereby acquire a high degree of expertise.

  • thalamic stimulation
  • essential tremor

https://doi.org/10.1136/jnnp.74.10.1387

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    Footnotes

    • ↵* At the time of the study ST was working at CHU de Grenoble, France

    • OS, ST, and JDS evaluated the patients in their group and wrote the paper, together with FA who performed the surgical procedures in his group. Study group collaborators included a neurosurgeon and a neurologist at each centre. They evaluated and implanted the patients. They also reviewed and provided comments on the paper. Members of the group were: P Pollak, A Benabid (CHU de Grenoble, France), O Sydow, B Meyerson (Karolinska Hospital, Stockholm, Sweden), R Ekberg, S Rehncrona (University Hospital, Lund, Sweden), B Johnels,L Augustinsson (Sahlgrenska University Hospital, Göteborg, Sweden), F von Raison, J N=Guyen (Hôpital Henri Mondor, Créteil, France), F Johansson, M Hariz (University Hospital, Umeå, Sweden), M Pinter, F Alesch (AKH Wien, Vienna, Austria), J D Speelman, D A Bosch (Academic Medical Centre, Amsterdam, Netherlands).

    • Competing interests: Medtronic financed the study and also supported the investigators as follows: OS, FA, and JDS received reimbursements for attending symposia; OS and JDS received unrestricted funds for research; FA and JDS received fees for organising education; JDS also received fees for consulting. ST declared no competing interest.

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