Longitudinal change in clinical, neurophysiological and MRI parameters in patients with motor neuron disease between baseline and 4 months
| Parameter | Change from baseline to 4 months (95% CI) | t Value (df) | P value | SRM |
| ALSFRS-R score (% change from baseline) | −3.5 (−5.2 to –1.8); −7.3% (−10.8% to −3.8%) | −4.2 (21) | <0.001 | −0.90 |
| Total MRC score | −8.4 (−11.1 to –5.8) | −6.6 (21) | <0.001 | −1.40 |
| MRC score right biceps | −0.2 (−0.528 to 0.007) | −2.0 (21) | 0.057 | −0.43 |
| MRC score left biceps | −0.4 (−0.7 to –0.1) | −2.6 (21) | 0.017 | −0.55 |
| MRC score right TA | −0.8 (−1.3 to –0.3) | −3.1 (21) | 0.005 | −0.67 |
| MRC score left TA | −0.9 (−1.5 to –0.3) | −3.0 (21) | 0.007 | −0.64 |
| Dynamometry right TA (lb) | −4.6 (−10.6 to 1.4) | −1.6 (21) | 0.128 | −0.34 |
| Dynamometry left TA (lb) | −8.3 (−15.1 to –1.5) | −2.5 (21) | 0.019 | −0.54 |
| Weight (kg) | −0.7 (−2.0 to 0.7) | −1.1 (17) | 0.302 | −0.25 |
| MUNIX biceps | −17.4 (−35.0 to 0.1) | −2.1 (18) | 0.052 | −0.48 |
| CMAP biceps | −0.7 (−1.3 to –0.2) | −2.7 (18) | 0.016 | −0.61 |
| MUSIX biceps | 2.4 (−2.6 to 7.4) | 1.0 (18) | 0.326 | 0.23 |
| MUNIX TA | −11.0 (−17.9 to –4.0) | −3.3 (17) | 0.004 | −0.78 |
| CMAP TA | −0.2 (−0.7 to 0.2) | −1.2 (17) | 0.239 | −0.29 |
| MUSIX TA | 4.1 (−6.5 to 14.7) | 0.8 (17) | 0.428 | 0.19 |
| T2 signal whole-body average (% change from baseline) | −0.01 (−0.04 to 0.02); −2.4% (−5.6% to 10.3%) | 0.6 (21) | 0.542 | 0.13 |
| T2 signal from muscle region of clinical onset (% change) | 0.02 (−0.02 to 0.05); 4.7% (−0.5% to 14.4%) | 1.0 (21) | 0.322 | 0.22 |
| T2 signal tongue (% change) | −0.02 (−0.07 to 0.02); −3.4% (−9.9% to 3.0%) | −1.1 (21) | 0.282 | −0.24 |
| T2 signal right biceps (% change) | −0.01 (−0.07 to 0.04); −3.1% (−17.5% to 11.3%) | −0.5 (21) | 0.656 | −0.10 |
| T2 signal left biceps (% change) | −0.05 (−0.10 to 0.01); −23.1% (−52.7% to 6.6%) | −1.6 (21) | 0.121 | −0.34 |
| T2 signal thoracic paraspinals (% change) | 0.05 (−0.10, 0.01); −10.6% (−23.1% to 1.8%) | −1.8 (21) | 0.091 | −0.38 |
| T2 signal right TA (% change) | 0.04 (0.01 to 0.07); 10.2% (2.0% to 18.4%) | 2.6 (21) | 0.017 | 0.55 |
| T2 signal left TA (% change) | 0.03 (0.01 to 0.06); 14.1% (3.4% to 24.9%) | 2.7 (21) | 0.013 | 0.58 |
Parameter estimates and P values refer to paired t-tests. Significant changes after correction for multiple comparisons are highlighted in bold.
ALSFRS-R, amyotrophic lateral sclerosis functional rating scale-revised; CMAP, compound muscle action potential; MRC, Medical Research Council; MUNIX, motor unit number index; MUSIX, motor unit number size; SRM, standardised response mean; TA, tibialis anterior.