Abstract
Little information is available concerning olfactory processing in frontotemporal lobar degeneration (FTLD). We undertook a case-control study of olfactory processing in three male patients fulfilling clinical criteria for FTLD. Odour identification (semantic analysis) and odour discrimination (perceptual analysis) were investigated using tests adapted from the University of Pennsylvania Smell Identification Test. General neuropsychometry and structural volumetric brain magnetic resonance imaging (MRI) were also performed. The three patients with FTLD exhibited a disorder of olfactory processing with the characteristics of a predominantly semantic (odour identification) deficit. This olfactory deficit was more prominent in patients with greater involvement of the temporal lobes on MRI. Central deficits of odour identification may be more common in FTLD than previously recognised, and these deficits may assist in clinical characterisation.
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Ratnavalli E, Brayne C, Dawson K, Hodges JR (2002) The prevalence of frontotemporal dementia. Neurology 58:1615–1621
Whitwell JL, Josephs KA, Rossor MN, Stevens JM, Revesz T, Holton JL, Al- Sarraj S, Godbolt AK, Fox NC, Warren JD (2005) Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia. Arch Neurol 62:1402–1408
Hodges JR, Davies R, Xuereb J, et al. (2004) Clinicopathological correlates in frontotemporal dementia. Ann Neurol 56:399–406
Rosen HJ, Gorno-Tempini ML, Goldman WP, et al. (2002) Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology 58:198–208
Rosen HJ, Perry RJ, Murphy J, et al. (2002) Emotion comprehension in the temporal variant of frontotemporal dementia. Brain 125:2286–2295
Gorno-Tempini ML, Dronkers NF, Rankin KP, et al. (2004) Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol 55:335–346
Doty RL (2001) Olfaction. Annu Rev Psychol 52:423–452
Hawkes C (2003) Olfaction in neurodegenerative disorder. Mov Disord 18:364–372
Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E (1992) Functional localization and lateralization of human olfactory cortex. Nature 360:339–340
Royet JP, Koening O, Gregoire MC, et al. (1999) Functional anatomy of perceptual and semantic processing for odours. J Cogn Neurosci 11:94–109
Gottfried JA, Deichmann R, Winston JS, Dolan RJ (2002) Functional heterogeneity in human olfactory cortex: an event-related functional magnetic resonance imaging study. J Neurosci 22:10819–10828
Savic I (2002) Brain imaging studies of the functional organization of human olfaction. Neuroscientist 8:204–211
Kareken DA, Mosnik DM, Doty RL, Dzemidzic M, Hutchins GD (2003) Functional anatomy of human odour sensation, discrimination, and identification in health and aging. Neuropsychology 17:482–495
Zelano C, Sobel N (2005) Humans as an animal model for systems-level organization of olfaction. Neuron 48:431–454
Zatorre RJ, Jones-Gotman M (1991) Human olfactory discrimination after unilateral frontal or temporal lobectomy. Brain 114:71–84
Jones-Gotman M, Zatorre RJ (1993) Odour recognition memory in humans: role of right temporal and orbitofrontal regions. Brain Cogn 22:182–198
West SE, Doty RL (1995) Influence of epilepsy and temporal lobe resection on olfactory function. Epilepsia 36:531–542
Jones-Gotman M, Zatorre RJ, Cendes F, et al. (1997) Contribution of medial versus lateral temporal-lobe structures to human odour identification. Brain 120:1845–1856
Mendez MF, Ghajarnia M (2001) Agnosia for familiar faces and odours in a patient with right temporal lobe dysfunction. Neurology 57:519–521
McKhann GM, Albert MS, Grossman M, Miller B, Dickson D, Trojanowski JQ (2001) Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurol 58:1803–1809
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198
Warrington EK (1984) Recognition Memory Test. NFER-Nelson, Windsor (UK)
Warrington EK (1997) The Graded Naming Test: A restandardisation. Neuropsychol Rehab 7:143–146
Doty RL, Shaman P, Dann M (1984) Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 32:489–502
Doty RL (1995) The Smell Identification Test™ Administration Manual. 3rd Edition. Sensonics, Inc., Haddon Hts (NJ)
Doty RL, Marcus A, Lee WW (1996) Development of the 12-item Cross- Cultural Smell Identification Test (CCSIT). Laryngoscope 106:353–356
Snowden JS, Thompson JC, Neary D (2004) Knowledge of famous faces and names in semantic dementia. Brain 127:860–872
Zatorre RJ, Jones-Gotman M (1990) Right-nostril advantage for discrimination of odours. Percept Psychophys 47:526–531
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Rami, L., Loy, C.T., Hailstone, J. et al. Odour identification in frontotemporal lobar degeneration. J Neurol 254, 431–435 (2007). https://doi.org/10.1007/s00415-006-0379-5
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DOI: https://doi.org/10.1007/s00415-006-0379-5