Lesion heterogeneity in multiple sclerosis: a study of the relations between appearances on T1 weighted images, T1 relaxation times, and metabolite concentrations

P A Brex; G J M Parker; S M Leary; P D Molyneux; G J Barker; C A Davie; A J Thompson; D H Miller

doi:10.1136/jnnp.68.5.627

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Paper

Lesion heterogeneity in multiple sclerosis: a study of the relations between appearances on T1 weighted images, T1 relaxation times, and metabolite concentrations

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Online download statistics by month: April 2000 to March 2024

	Abstract	Full	Pdf
Apr 2000	32	55	19
May 2000	22	39	13
Jun 2000	6	13	8
Jul 2000	6	10	6
Aug 2000	6	12	11
Sep 2000	1	10	17
Oct 2000	5	7	8
Nov 2000	5	8	5
Dec 2000	3	6	4
Jan 2001	1	2	0
Feb 2001	1	8	5
Mar 2001	0	6	2
Apr 2001	2	7	1
May 2001	4	21	2
Jun 2001	1	6	1
Jul 2001	0	7	4
Aug 2001	0	8	1
Sep 2001	3	7	4
Oct 2001	2	11	4
Nov 2001	4	12	6
Dec 2001	1	3	3
Jan 2002	1	15	8
Feb 2002	0	14	6
Mar 2002	1	13	7
Apr 2002	0	52	1
May 2002	5	11	6
Jun 2002	3	13	4
Jul 2002	1	17	4
Aug 2002	1	6	5
Sep 2002	0	9	7
Oct 2002	0	8	6
Nov 2002	2	9	9
Dec 2002	6	11	12
Jan 2003	1	8	12
Feb 2003	2	8	5
Mar 2003	3	16	12
Apr 2003	0	7	4
May 2003	4	5	8
Jun 2003	0	9	10
Jul 2003	0	9	9
Aug 2003	1	5	2
Sep 2003	2	8	4
Oct 2003	2	9	2
Nov 2003	0	4	2
Dec 2003	1	3	3
Jan 2004	2	6	6
Feb 2004	1	8	9
Mar 2004	2	10	8
Apr 2004	1	6	7
May 2004	1	12	5
Jun 2004	7	12	9
Jul 2004	46	58	8
Aug 2004	40	64	5
Sep 2004	16	39	8
Oct 2004	13	40	4
Nov 2004	7	76	20
Dec 2004	15	58	15
Jan 2005	10	52	8
Feb 2005	14	80	16
Mar 2005	14	43	6
Apr 2005	6	25	7
May 2005	23	35	10
Jun 2005	14	35	7
Jul 2005	17	14	7
Aug 2005	16	37	10
Sep 2005	15	30	13
Oct 2005	12	29	9
Nov 2005	12	24	16
Dec 2005	6	20	12
Jan 2006	9	23	8
Feb 2006	15	25	6
Mar 2006	13	22	5
Apr 2006	19	22	6
May 2006	4	18	3
Jun 2006	12	9	8
Jul 2006	11	9	7
Aug 2006	7	13	2
Sep 2006	12	16	4
Oct 2006	7	26	9
Nov 2006	9	27	5
Dec 2006	5	26	7
Jan 2007	3	27	7
Feb 2007	6	32	10
Mar 2007	9	24	12
Apr 2007	25	13	4
May 2007	22	4	4
Jun 2007	16	5	5
Jul 2007	10	5	2
Aug 2007	13	8	5
Sep 2007	17	4	6
Oct 2007	17	6	4
Nov 2007	19	6	4
Dec 2007	10	3	6
Jan 2008	11	9	8
Feb 2008	9	6	5
Mar 2008	13	4	18
Apr 2008	13	7	9
May 2008	14	5	6
Jun 2008	11	3	2
Jul 2008	8	3	3
Aug 2008	18	5	8
Sep 2008	26	3	4
Oct 2008	33	3	3
Nov 2008	4	3	4
Dec 2008	5	1	2
Jan 2009	9	5	3
Feb 2009	11	5	3
Mar 2009	6	3	3
Apr 2009	6	1	2
May 2009	5	0	2
Jun 2009	7	0	1
Jul 2009	11	0	1
Aug 2009	6	0	1
Sep 2009	7	1	0
Oct 2009	18	1	2
Nov 2009	18	5	0
Dec 2009	19	0	3
Jan 2010	6	2	4
Feb 2010	5	0	2
Mar 2010	2	2	4
Apr 2010	13	7	2
May 2010	4	5	0
Jun 2010	9	0	2
Jul 2010	5	2	3
Aug 2010	10	2	1
Sep 2010	18	7	1
Oct 2010	23	4	2
Nov 2010	26	9	5
Dec 2010	14	7	4
Jan 2011	11	2	1
Feb 2011	23	9	5
Mar 2011	36	8	0
Apr 2011	34	4	0
May 2011	21	7	0
Jun 2011	19	11	1
Jul 2011	15	2	0
Aug 2011	20	0	1
Sep 2011	19	1	0
Oct 2011	19	5	1
Nov 2011	11	14	5
Dec 2011	13	18	5
Jan 2012	9	24	3
Feb 2012	9	22	4
Mar 2012	14	18	4
Apr 2012	8	15	9
May 2012	11	24	25
Jun 2012	19	14	8
Jul 2012	9	13	11
Aug 2012	14	11	9
Sep 2012	15	25	13
Oct 2012	11	15	7
Nov 2012	25	23	7
Dec 2012	16	12	14
Jan 2013	16	14	11
Feb 2013	11	7	10
Mar 2013	10	10	8
Apr 2013	16	9	17
May 2013	18	18	24
Jun 2013	9	9	4
Jul 2013	16	8	14
Aug 2013	8	10	6
Sep 2013	9	4	2
Oct 2013	15	8	16
Nov 2013	17	7	8
Dec 2013	7	6	15
Jan 2014	10	8	10
Feb 2014	9	5	7
Mar 2014	11	5	14
Apr 2014	19	11	16
May 2014	16	8	10
Jun 2014	5	6	9
Jul 2014	19	37	23
Aug 2014	8	37	7
Sep 2014	7	53	11
Oct 2014	12	120	5
Nov 2014	11	79	2
Dec 2014	8	18	1
Jan 2015	7	27	8
Feb 2015	1	8	5
Mar 2015	10	9	7
Apr 2015	5	15	1
May 2015	6	14	3
Jun 2015	1	1	5
Jul 2015	5	4	4
Aug 2015	9	1	5
Sep 2015	10	5	2
Oct 2015	10	1	2
Nov 2015	13	2	0
Dec 2015	8	7	5
Jan 2016	13	2	2
Feb 2016	7	4	4
Mar 2016	9	5	3
Apr 2016	1	5	5
May 2016	5	7	2
Jun 2016	8	0	8
Jul 2016	11	1	3
Aug 2016	10	3	3
Sep 2016	11	4	6
Oct 2016	14	4	4
Nov 2016	10	2	7
Dec 2016	14	2	0
Jan 2017	11	0	5
Feb 2017	1	1	1
Mar 2017	3	9	3
Apr 2017	3	13	3
May 2017	6	12	6
Jun 2017	8	7	4
Jul 2017	10	8	5
Aug 2017	3	3	2
Sep 2017	15	9	3
Oct 2017	19	9	4
Nov 2017	16	14	6
Dec 2017	10	8	0
Jan 2018	19	11	0
Feb 2018	19	13	5
Mar 2018	20	8	3
Apr 2018	16	12	4
May 2018	16	10	4
Jun 2018	15	15	4
Jul 2018	10	4	6
Aug 2018	23	21	13
Sep 2018	42	42	8
Oct 2018	41	37	4
Nov 2018	64	60	7
Dec 2018	52	49	7
Jan 2019	58	50	7
Feb 2019	40	41	5
Mar 2019	27	21	18
Apr 2019	21	17	8
May 2019	14	12	9
Jun 2019	14	10	14
Jul 2019	16	14	5
Aug 2019	19	17	8
Sep 2019	12	12	2
Oct 2019	37	26	12
Nov 2019	27	23	4
Dec 2019	22	20	8
Jan 2020	35	27	5
Feb 2020	21	11	6
Mar 2020	14	12	7
Apr 2020	12	10	2
May 2020	25	11	15
Jun 2020	23	23	7
Jul 2020	28	26	3
Aug 2020	17	9	17
Sep 2020	34	28	23
Oct 2020	23	17	5
Nov 2020	46	36	20
Dec 2020	52	30	22
Jan 2021	43	34	13
Feb 2021	50	44	8
Mar 2021	55	45	14
Apr 2021	50	30	8
May 2021	48	43	17
Jun 2021	31	31	7
Jul 2021	31	31	17
Aug 2021	34	33	13
Sep 2021	45	44	4
Oct 2021	63	50	25
Nov 2021	24	18	26
Dec 2021	54	46	5
Jan 2022	58	48	10
Feb 2022	50	42	12
Mar 2022	50	37	9
Apr 2022	38	34	5
May 2022	73	55	28
Jun 2022	56	52	14
Jul 2022	49	32	5
Aug 2022	60	54	12
Sep 2022	45	37	10
Oct 2022	61	59	13
Nov 2022	33	31	6
Dec 2022	58	53	3
Jan 2023	71	61	20
Feb 2023	80	59	16
Mar 2023	91	76	10
Apr 2023	48	48	11
May 2023	43	31	10
Jun 2023	54	49	6
Jul 2023	66	57	8
Aug 2023	70	66	6
Sep 2023	62	57	11
Oct 2023	77	52	16
Nov 2023	87	82	4
Dec 2023	249	13	5
Jan 2024	41	0	1
Feb 2024	60	8	0
Mar 2024	123	2	1
Total	5510	5282	1984

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